Introduction Knee osteoarthritis is one of the most common joint disorders worldwide and a leading cause of pain and disability among adults. This condition occurs when the protective cartilage that cushions the ends of the bones within the knee joint gradually wears away over time. As the cartilage deteriorates, the bones begin to rub against each other, causing pain, stiffness, swelling, and reduced mobility. Millions of people suffer from knee osteoarthritis, and its prevalence continues to rise due to aging populations, increasing obesity rates, and sedentary lifestyles. Although osteoarthritis is commonly associated with older adults, younger individuals may also develop the condition as a result of injuries, genetic factors, or excessive stress on the joint. This comprehensive guide explores everything you need to know about knee osteoarthritis, including its causes, symptoms, diagnosis, treatment options, prevention strategies, and the latest medical advancements. What is ...
Cerebrovascular Accidents in Sickle Cell Disease: Rates and Risk Factors Abstract Cerebrovascular accident (CVA) is a major complication of sickle cell disease. The incidence and mortality of and risk factors for CVA in sickle cell disease patients in the United States have been reported only in small patient samples. The Cooperative Study of Sickle Cell Disease collected clinical data on 4,082 sickle cell disease patients enrolled from 1978 to 1988. Patients were followed for an average of 5.2 ± 2.0 years. Age-specific prevalence and incidence rates of CVA in patients with the common genotypes of sickle cell disease were determined, and the effects of hematologic and clinical events on the risk of CVA were analyzed. The highest rates of prevalence of CVA (4.01%) and incidence (0.61 per 100 patient-years) were in sickle cell anemia (SS) patients, but CVA occurred in all common genotypes. The incidence of infarctive CVA was lowest in SS patients 20 to 29 years of age and higher in...